Medical therapy reduces microbiota diversity and evenness in surgically recalcitrant chronic rhinosinusitis
نویسندگان
چکیده
منابع مشابه
Microbiome therapy of recalcitrant chronic rhinosinusitis
Background: Chronic or recurrent rhinosinusitis (CRS) is a disease associated with impaired quality of life and substantial societal costs. Many cases present without a clear underlying cause and despite the lack of etiology current treatment protocols dictate intervention with antibiotics, anti-inflammatory drugs or surgery often with poor long-term outcome. Recent studies indicate that commen...
متن کاملOsteitic bone in recalcitrant chronic rhinosinusitis.
INTRODUCTION There is increasing interest in the underlying bone of the paranasal sinuses as an important player in recalcitrant Chronic Rhinosinusitis. Close inspection of CT scans often reveals areas of increased bone density and irregular thickening of the sinus walls. This osteitic bone could at least partly explain, why inflammation of the mucosa persists. METHODS We searched PubMed for ...
متن کاملNasal lavage with mupirocin for the treatment of surgically recalcitrant chronic rhinosinusitis.
OBJECTIVES/HYPOTHESIS To examine the efficacy and tolerability of topical mupirocin for the management of surgically recalcitrant chronic rhinosinusitis (CRS) associated with Staphylococcus aureus infection. STUDY DESIGN Prospective open-label pilot study. METHODS Patients with surgically recalcitrant CRS who had positive nasendoscopically guided cultures for Staphylococcus aureus were trea...
متن کاملEfficacy of medical therapy in treatment of chronic rhinosinusitis
Uncomplicated chronic rhinosinusitis (CRS) is generally treated with medical therapy initially and surgery is contemplated only after medical therapy has failed. However, there is considerable variation in the medical treatment regimens used and studies defining their efficacy are few. The aim of this study was to determine the proportion of patients treated medically who responded sufficiently...
متن کاملChronic rhinosinusitis: epidemiology and medical management.
Chronic rhinosinusitis (CRS) affects 12.5% of the US population. On epidemiologic grounds, some association has been found between CRS prevalence and air pollution, active cigarette smoking, secondhand smoke exposure, perennial allergic rhinitis, and gastroesophageal reflux. The majority of pediatric and adult patients with CRS are immune competent. Data on genetic associations with CRS are sti...
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ژورنال
عنوان ژورنال: International Forum of Allergy & Rhinology
سال: 2013
ISSN: 2042-6976
DOI: 10.1002/alr.21195